HIV-1 infection results in a decrease of CD4 T cells, an increase of CD8 T cells, a decrease in the CD4:CD8 ratio, and a progressive destruction of immune function. In HIV-1 seropositive patients, enumeration of CD4 T cells may be used for prognostic purposes and to monitor disease progression and antiretroviral therapy.

The CD4:CD8 Ratio Profile Includes:

Percentage CD3⁺CD4⁺; absolute CD3⁺CD4⁺; percentage CD3⁺CD8⁺; absolute CD3⁺CD8⁺; CD4:CD8 ratio; CBC with differential